Nancy Gerlach reports:
If we define a sandwich as two slices of bread filled with a variety of meats, cheeses, relishes, fillings, and/or vegetables, then Rabbi Hillel the Elder was the first recorded creator of the sandwich, in the first century BC. Hillel put apple slices, nuts, and spices between matzos to eat during Passover, a dish which is still served at Seder and is now called the Hillel Sandwich. Read the entire article, plus recipes, here.